Uncle Buck

John Candy

Buck Russell

Jean Louisa Kelly

Tia Russell

Gaby Hoffmann

Maizy Russell

Macaulay Culkin

Miles Russell

Amy Madigan

Chanice Kobolowski

Elaine Bromka

Cindy Russell

Garrett M. Brown

Bob Russell

Laurie Metcalf

Marcie Dahlgren-Frost

Jay Underwood

Bug

Brian Tarantina

E. Roger Coswell

Mike Starr

Pooter-the-Clown

Suzanne Shepherd

Mrs. Hogarth

William Windom

Mr. Hatfield (voice)

Dennis Cockrum

Pal

Joel Robinson

Miles' Friend #1

Colin Baumgartner

Miles' Friend #2

Erik Whipple

Miles' Friend #3

Mark Rosenthal

Party Boy #1