Cyrus

John C. Reilly

John Kilpatrick

Jonah Hill

Cyrus Fawcett

Marisa Tomei

Molly Fawcett

Catherine Keener

Jamie

Matt Walsh

Tim

Kathy Ann Wittes

Ashley

Diane Mizota

Thermostat Girl

Katie Aselton

Pretty Girl

Jamie Donnelly

Pastor

Tim Guinee

Roger

Steve Zissis

Rusty

Bill 'Bunky' Miller

Cyrus

Charlie Brewer

Stranger at Reception

Mitch Carter

Additional Voice (voice)

Newell Alexander

Additional Voice (voice)

Steve Alterman

Additional Voice (voice)