Drugstore Cowboy

Matt Dillon

Bob

Kelly Lynch

Dianne

James Remar

Gentry

James Le Gros

Rick

Heather Graham

Nadine

Beah Richards

Drug Counselor

Grace Zabriskie

Bob's Mother

Max Perlich

David

William S. Burroughs

Tom the Priest

Eric Hull

Druggist

John Kelly

Cop

George Catalano

Trousinski

Janet Baumhover

Neighbor Lady

Ted D'Arms

Neighbor Man

Neal Thomas

Halamer

Stephen Rutledge

Hotel Manager

Robert Lee Pitchlynn

Hotel Clerk

Roger Hancock

Machinist