Desperately Seeking Susan

Rosanna Arquette

Roberta Glass

Madonna

Susan

Aidan Quinn

Dez

Mark Blum

Gary Glass

Robert Joy

Jim

Laurie Metcalf

Leslie Glass

Anna Thomson

Crystal

Will Patton

Wayne Nolan

Steven Wright

Larry Stillman D.D.S.

John Turturro

Ray

Giancarlo Esposito

Street Vendor

Richard Hell

Bruce Meeker

Rockets Redglare

Taxi Driver

Annie Golden

Band Singer

Richard Edson

Man With Newspapers

Ann Magnuson

Cigarette Girl

John Lurie

Neighbor Saxophonist

Peter Maloney

Ian