The Big C

Laura Linney

Cathy Jamison

John Benjamin Hickey

Sean Tolkey

Oliver Platt

Paul Jamison

Phyllis Somerville

Marlene

Gabourey Sidibe

Andrea Jackson

Gabriel Basso

Adam Jamison

Phill Lewis

Cool pool boss

Emily Kinney

Emily

Michael Chernus

Pastor Rick

Judy Gold

Rabbi

Rebecca Watson

Blonde Woman (uncredited)

Liz Holtan

Amber

E.J. Bonilla

Scott

Angela Lewis

Day Nurse

Cynthia Nixon

Rebecca

Reid Scott

Todd Mauer

Ned Eisenberg

Dr. Volimer

Ann Harada

Brenda